Effect of Intralesional Injection of Triamcinolone Acetonide in Oral Sub-Mucous Fibrosis

Hyder Ali, Sufyan Ahmed, Syeda Hala Raza

  • Hyder Ali Department of Plastic & Reconstructive Surgery Dow University of Health Sciences Dr Ruth KM Pfau Civil Hospital Karachi



To assess the effectiveness in terms of improvement in mouth opening after intralesional injection of triamcinolone acetonide in oral sub-mucous fibrosis (OSMF).

Study design

Cross sectional study.

Place & Duration of study

Department of Plastic Surgery Dow University of Health Sciences & Dr. Ruth KM Pfau Civil Hospital Karachi, and Oral and Maxillofacial Surgery Department Abbasi Shaheed Hospital Karachi, from May 2017 to April 2018.


This study included patients of either gender with the history of chewing of areca nut and clinically diagnosed as having OSMF (mouth opening between 10 -25mm). Patients with trismus due to temporo-mandibular joint (TMJ) problems, and previously treated OSMF were excluded. Triamcinolone acetonide 40mg at weekly interval for consecutive six weeks were given intralesionally and patients were followed for six months. Outcome in terms of improvement in mouth opening (i.e. inter-incisal distance in millimeters) was measured using vernier caliper. Data was analyzed by using SPSS version 20.


This study included 60 patients with the age between 20 to 45 years. There was marked improvement in mouth opening. In paired comparison statistically significant difference t= -31.157, P<0.001 with mean 9.367+2.329, 95% Confidence Interval of the difference lower-9.968 upper-8.765 was observed.


Intralesional injections of triamcinolone acetonide resulted in significant improvement in patients with OSMF in terms of mouth opening.

Key words

Intralesional injection, Oral submucous fibrosis, Triamcinolone acetonide.