Comparison of Oral Nifedipine and Vaginal Progesterone In Prolongation of Pregnancy With Preterm Labor

Maryam Arif, Sadaf Zohra, Umairah Yaqub

  • Maryam Arif Department of Obstetrics & Gynaecology Military Hospital, Rawalpindi



To compare the effectiveness of oral nifedipine and vaginal progesterone in prolongation of the duration of pregnancy with preterm labor.

Study design

Comparative study.

Place & Duration of study

Department of Obstetrics and Gynecology, Military Hospital Rawalpindi, from March 2016 to September 2016.


A total of 90 women with singleton pregnancy, 18 to 39 years of age were included. Patients with polyhydramnios, preterm pre-labor rupture of membranes, gestational hypertension, pre-eclampsia and eclampsia were excluded. Using the lottery method, the selected patients were placed randomly assigned into two groups, Group A in which nifedipne was used and Group B where progesterone was given. Frequency of prolongation of duration of labor was noted for both the groups.


In Group A mean age of the women was 28.31.±_5.88 year and mean gestational age 32.33.±_2.62 weeks; while in Group B mean age was 29.58± 5.11 year and mean gestational age 32.47 ± 2.24 weeks. Mean prolongation of pregnancy in nifedipine and progesterone group was 17.39.±11.71 weeks and 47.42± 12.29 weeks respectively. Prolongation of the duration of pregnancy was seen in 33 (73.33%) in group A and 42 (93.33%) in group B with p=0.011.


Effectiveness of vaginal progesterone was higher in prolongation of the duration of pregnancy with preterm labour as compared to oral nifedipine.

Key words

Pregnancy prolongation, Nifedipine, Progesterone.